GSDMD and Sepsis: Finally, in order to prove that AFT accelerated mouse death by increasing GSDMD-mediated pyroptosis, we treated Gsdmd−/− mice with fluconazole or applied a GSDMD inhibitor, disulfiram, which could inhibit pore formation on cell membrane by GSDMD N-terminal fragment and thus halt pyroptosis-mediated sepsis progressing [35].