High numbers of CD103+ CD8+ Trm were found in the mucosa of CD patients and controls, but those from patients had a more prominent Th17 profile. KLRG1+ CD8+ Trm cells were increased in inflammatory conditions. In Crohn ́s disease patients the CD103+ CD8+ T cells might alert the effector KLRG1+ CD8+ T subset. The gene discussed is ITGAE; the disease is Crohn disease.