In this review, we summarized the references and presented that as the checkpoint, NLRP3 inflammasome connects innate and adaptive immunity in several autoimmune diseases, including inflammatory bowel disease, psoriasis, rheumatoid arthritis, systemic sclerosis, type 1 diabetes, systemic lupus erythematosus, and autoimmune thyroid diseases. The gene discussed is NLRP3; the disease is psoriasis.