Collectively, the effect of NLRP3 inflammasome in autoimmune diseases involves the following two aspects (Table 2 and Figure 2): due to caspase-1 being the effector of inflammasome structure, IL-1β, IL-18, and pyroptosis modulated by activated caspase-1 play a major role in autoimmune diseases. Here, NLRP3 is linked to autoimmune disease.