GZMB and neoplasm: In human, CD103+ TRM cells can also produce granzyme B (GZMB) and IFN-γ, which can restrict tumor cell growth and metastasis by inducing fibronectin production, make antigens available to prime for the priming of new tumor-specific T cells, and enhance recruitment of monocytes, NK cells, and XCR1+ cDC1 to the tumor site (9).