CD4 and neoplasm: To generate an activation gene set that could be used as a proxy of tumor-specific TIL activation, we analyzed the entire transcriptome of TILs following recognition of autologous TCLs [in-house bulk RNA sequencing data obtained from 12 CD8+ (10 MM, 1 SAR, 1 OC) and 11 CD4+ enriched TIL samples (MM)].