CD4 and neoplasm: Overall, as only TILs with high level of recognition were used, the mean percentage of “bulk” TILs that were reactive to autologous tumor cells was high (measured with upregulation of CD137, TNF, IFNγ or CD107a: 41% in CD8+ TILs, n=21; and 29% in CD4+ TILs, n=16.