Despite most genes being highly expressed in ENTPD1+ and/or ITGAE+ positive clusters, we could still observe the expression of genes such as TNF or IL5, for the CD8+ compartment, or CXCL9 or SOD2, for the CD4+ compartment, within the ENTPD1- ITGAE- cluster, indicating that CD39 and CD103 may be useful but not sufficient to discriminate the entire repertoire of tumor-specific reactive TILs in situ (Figures 4B, C). This evidence concerns the gene CD8A and neoplasm.