TNF and neoplasm: When sub-grouping the total tumor-specific reactive TILs based on upregulation of CD137 only (CD137+ Antitumor function-), upregulation/mobilization of at least one among TNF, IFNγ, and CD107a without CD137 (CD137- Antitumor function+), or both (CD137+ Antitumor function+), we observed that all three populations were well represented within the total reactive CD8+ TILs: on average, 21% were CD137+ Antitumor function-, 26% were CD137- Antitumor function+, and 53% were CD137+ Antitumor function+ (Figure 2E and Supplementary Figure 5A).