Hence, we investigated whether genes coding for some of the most commonly used T cell activation molecules (TNF, IFNγ, IL-2, CD107a, CD154, CD137, GZMB) were upregulated in in-house bulk RNA sequencing data obtained from 12 CD8+ (10 MM, 1 SAR, 1 OC) and 11 CD4+ enriched TIL samples (MM) following recognition of naturally-presented autologous tumor antigens. This evidence concerns the gene CD8A and neoplasm.