The overexpression of the human IL-8 gene in mice could also increase hepatic neutrophil infiltration and facilitate the progression of fatty liver to NASH; the concomitant overexpression of Cxcl1 and IL-8 further amplified the effect of the single overexpression of either Cxcl1 or IL-8 (89). The gene discussed is CXCL1; the disease is metabolic dysfunction-associated steatohepatitis.