In addition, CXCL1-induced NASH was ameliorated by treatment with IL-22, which is a cytokine produced by immune cells such as Th17, Th22, and type 3 innate lymphoid cells (ILC3s) (99) but acts on epithelial cells, including hepatocytes, by upregulating various genes with cytoprotective and anti-oxidative properties (100, 101). This evidence concerns the gene CXCL1 and metabolic dysfunction-associated steatohepatitis.