CXCL1 and metabolic dysfunction-associated steatohepatitis: CXCL1-induced liver injury in HFD-fed mice was found to be dependent on neutrophil cytosolic factor 1 (also known as p47phox), which is one of the components of the NADPH oxidase 2 complex that mediates oxidative burst (97, 98), corroborating the importance of neutrophilic ROS production in neutrophil-driven NASH development (16).