reported that LCN2 mRNA levels were increased by more than 28-folds in a high-fat, high-sugar-induced NASH mouse model; their protein-protein interaction analysis using Search Tool for the Retrieval of Interacting Genes (STRING, http://string-db.org) database supported the notion that LCN2 might physically interact with various inflammatory mediators (e.g., IL-1R2, IL-3, IL-6, IL-18, and IL-17A) or might be involved in the inflammatory cascades mediated by inflammatory mediators (137). The gene discussed is IL6; the disease is metabolic dysfunction-associated steatohepatitis.