Specifically, the authors found that the expression of alanine aminotransferases was increased in the liver in mice with obesity and diabetes, as well as in humans with type 2 diabetes, and hepatocyte-selective silencing of alanine aminotransferase enzymes in mice with obesity and diabetes retarded hyperglycemia and reversed skeletal muscle atrophy through restoration of skeletal muscle protein synthesis (25). This evidence concerns the gene GPT and diabetes mellitus.