FPR2 and obesity due to melanocortin 4 receptor deficiency: Moreover, a recent report suggested that the deletion of resolution sensor ALX/FPR2 is associated with the development of diastolic dysfunction related with obesity in mice with HFpEF (Tourki et al., 2020), supporting the concept of non-resolving inflammation in HFpEF (Tourki and Halade, 2021).