Some studies have shown that IL-33 concentrations are increased, positively correlated with TNF-α and N-terminal-pro-B-type-natriuretic peptide (NT-proBNP) and negatively correlated with LVEF in CHF patients (Zhang H.F. et al., 2012; Xiang et al., 2021). The gene discussed is NPPB; the disease is congestive heart failure.