IL-18 also increases the expression of vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) in endothelial cells and cardiomyocytes, thus increasing leukocyte recruitment into the injured myocardium and amplifying cardiac inflammation (Wang et al., 2008). The gene discussed is ICAM1; the disease is inflammatory response.