In CHF patients, CRP concentration has also been shown to be reduced by other drugs such as β-blockers (carvedilol) and angiotensin II receptor antagonists (valsartan), but not by the combination of valsartan with angiotensin converting enzyme inhibitors (Anand et al., 2005; Nessler et al., 2013). This evidence concerns the gene CRP and congestive heart failure.