MPO and myocardial infarction: Experimental studies using MPO knockout mice or an oral MPO inhibitor showed significant less left ventricle dilation and improved left ventricular function in models of myocardial infarction, evidencing a pathophysiological role of MPO in the development of CHF (Askari et al., 2003; Vasilyev et al., 2005; Ali et al., 2016).