In terms of immune regulation, intraperitoneal injection of recombinant mouse Tnfaip6 also reduced the infiltration of Tfh, increased Tfr, adjusted the imbalance of Tfh/Tfr ratios in the MLNs and spleen, and reduced inflammation, while MSCs failed to attenuate colitis or regulate the imbalance of the Tfh/Tfr ratio when Tnfaip6 was knocked down. Here, TFRC is linked to colitis.