In this study, we assessed the effects of bone marrow–derived (BM) MSCs on a 2,4,6-trinitrobenzene sulfonic acid (TNBS)–induced colitis mice model, together with the immunomodulatory effect on Tfh/Tfr, in order to identify the immunological mechanism of MSCs in the treatment of IBD. The gene discussed is TFRC; the disease is colitis.