Using the same data as before, we identified 3375 mRNAs to be significantly and differentially expressed in CD4+ T cells from SLE patients as compared to healthy controls (Supplementary Figure S1C), of which 1438 mRNAs were upregulated and 1937 mRNAs were downregulated (Supplementary Figure S1D). This evidence concerns the gene CD4 and systemic lupus erythematosus.