Many studies have found that a high-iron diet can lead to iron disorders and overexpression of Aβ and phosphorylated tau, and iron chelating agents such as DFP and DFO can play a preventive and therapeutic role, as well as a neuroprotective role (Guo et al., 2013; Sripetchwandee et al., 2016; Rao et al., 2020). Here, MAPT is linked to iron metabolism disease.