APOE is important in lipoprotein metabolism and immunoregulation strongly associated with cardiovascular and Alzheimer’s disease (Karch and Goate, 2015; Allen et al., 2016; Cacace et al., 2016; Yamazaki et al., 2016; Wang et al., 2018; Logsdon et al., 2019; Andrews et al., 2020; Bellenguez et al., 2020). Here, APOE is linked to Alzheimer disease.