These include variations in genes commonly associated with AD including ABCA7, PLCG2, CR1, BIN1, and SORL1. The new strains are prioritized for extensive phenotyping using a primary screening approach centered on transcriptional profiling of nearly 800 genes known to be differentially expressed in human AD brains compared to unaffected controls (Preuss et al., 2020). This evidence concerns the gene BIN1 and Alzheimer disease.