TREM2 and Alzheimer disease: Our results mirror some emerging evidence that APOEε4 suppresses Trem2*R47H in AD risk, that there are some suggestions that APOEε4 carriers do not have increased AD risk with Trem2*R47H and Trem2*R47H only increases the risk on APOEε3 carriers (Jendresen et al., 2017; Fitz et al., 2020).