TREM2 and early-onset autosomal dominant Alzheimer disease: Amyloid plaque formation is a primary diagnostic measure of Alzheimer’s disease with both APOE and TREM2 linked to amyloid deposition (McGeer et al., 1997; Blennow et al., 2006; Bilkei-Gorzo, 2014; Kanekiyo et al., 2014; Jay et al., 2015; Cacace et al., 2016; Dourlen et al., 2019; Parhizkar et al., 2019).