TREM2 and Alzheimer disease: Downregulated DEGs were enriched in multiple AD-related pathways such as “lysosome”, “osteoclast differentiation”, “phagosome”, “antigen processing and presentation”, cytokine-cytokine receptor interaction’, and “complement and coagulation cascades” in both 24 months old B6.Trem2*R47H and B6.APOE4.Trem2*R47H mice (Figure 7, Supplementary Figure 10).