SORL1 and Alzheimer disease: These include variations in genes commonly associated with AD including ABCA7, PLCG2, CR1, BIN1, and SORL1. The new strains are prioritized for extensive phenotyping using a primary screening approach centered on transcriptional profiling of nearly 800 genes known to be differentially expressed in human AD brains compared to unaffected controls (Preuss et al., 2020).