MAPT and Alzheimer disease: Interestingly, a reduction in Glut expression has been observed in the brains of patients with AD and in transgenic mouse models of AD, which exacerbates the pathology by increasing Aβ load and tau phosphorylation, accelerating cognitive impairment and promoting neuronal dysfunction (Liu et al., 2008; Shah et al., 2012; Winkler et al., 2015).