Indeed, NMNAT2 overexpression delays injury-induced axon degeneration both in vitro and in vivo (Feng et al., 2010; Yan et al., 2010; Ali et al., 2016) and alleviates neurodegeneration in the P301L mouse model of tauopathy (Ljungberg et al., 2012). This evidence concerns the gene NMNAT2 and tauopathy.