Thus, these results contrast dramatically with the significant neuroprotection effect of NMNAT2 in traumatic axonopathy and tauopathy (Feng et al., 2010; Gilley and Coleman, 2010; Yan et al., 2010; Ljungberg et al., 2012; Gilley et al., 2013, 2019; Milde et al., 2013b; Ali et al., 2016; Coleman and Hoke, 2020). Here, NMNAT2 is linked to tauopathy.