PTPRT plays some important physiological effects in protein metabolism; PTPRT rs6030462 mutations might affect some important protein phosphate, transmembrane transportation, and dephosphorylation to result in the degradation disorder of some neuron-proteins, subsequently producing some toxic proteins such as α-synuclein, TDP43, and FUS/TLS, which damage neural cells, contributing to sPD and sALS. This evidence concerns the gene FUS and Platelet storage pool disease.