In human clinical CRC tissues (n = 131) we found that the high KLF5 mRNA expression group had a worse prognosis than low KLF5 mRNA expression group when the cut-off point was set at a median value of KLF5 mRNA expression (P = 0.039, Fig. 3a and Supplementary Table S2). Here, KLF5 is linked to colorectal carcinoma.