PLOD1 and COVID-19: It is not clear if the increases in LH and decrease in testosterone are related to febrile illness or from the direct effects of SARS-CoV2 on testicular cells, but Temiz did show that the decrease in testosterone during active infection seems to be temporary and there is at least partial recovery after treatment and Kadihasanoglu found that there was a difference in LH and testosterone level in those with COVID-19 versus non-COVID-19 upper respiratory tract infections [33, 38].