In addition to this parameter, we also showed that sVCAM, NOX2, NOX4, and iNOS expression, as well as ROS production, vascular remodeling, cellular infiltration, fibrosis, mesangial expansion, and liver inflammation increased after AGII intraperitoneal administration, along with the concentration of TNFα, IFNγ, IL1β, VCAM-1, ICAM-1 and TGFβ. Here, NOX4 is linked to digestive system neoplasm.