MX2 and neoplasm: We, therefore, evaluated the correlation of Mx2 with the tumor resistance to oHSV-1 replication in this study and investigated the mechanism by which Mx2 influences oHSV-1 productive replication and even oncolytic activity, to offer potential targets to improve oHSV-1 oncolytic efficacy and develop candidates of biomarkers to predict the efficiency of oHSV-1 multiplication in tumors.