Finally, the production of both CCL2 and CXCL10 chemokines in the HSV-1-infected brain are responsible for recruiting CCR2+ and CXCR3+ monocytes respectively, as well as CXCR3+ T cells, which typically exacerbate HSE pathology24,26,27. The gene discussed is CXCL10; the disease is herpes simplex encephalitis.