CR intervention also significantly increased the frequencies of tumor-cytotoxic effector T cells (Eff CD8+ and CD4+) in the spleen and peripheral blood (Fig. 6g–j and Supplementary Fig. 8g–j), including cytotoxic granzyme B (GrB+) expressing effector T cells in the spleen, such as GrB+CD8+ and cytotoxic GrB+CD4+ (Fig. 6k, l, Supplementary Fig. 8k, l). This evidence concerns the gene CD4 and neoplasm.