BCAR3 and head and neck squamous cell carcinoma: To illustrate the effect of BCAR3 on HNSCC cell proliferation, we silenced BCAR3 in SCC25 and FaDu cells using two different shRNAs (shBCAR3-1 and shBCAR3-2); BCAR3 silencing was then verified by western blot analysis (Supplementary Fig. 2).