The PARylation inhibitory activity of cGAS-cGAMP-STING signaling might exacerbate chromosomal instability and hence might contribute to previously reported tumorigenesis4,12, tumor cell-autonomous metastasis8,105, and IR-induced cell death in rapidly dividing non-cancerous cells such as bone marrow cells in in vivo experiments13. Here, CGAS is linked to neoplasm.