KAT8 and metabolic syndrome: We observed that the free water content of Mof+/− mice on SD was comparable to that observed in the (obese) Mof+/+ mice on HFD, therefore not only corroborating the hypothesis that reduced Mof levels are associated with metabolic syndrome predisposition, but also ruling out the possibility that weight loss in Mof+/− animals is caused by water deprivation (Fig. 3h).