As NRIP1 is an overexpressed transcriptional coregulator in breast cancer, we focused on evaluating the genes that could be regulated by NRIP1. To evaluate the importance of NRIP1, we depleted this gene in the MCF7 and T47D cell lines using an siRNA approach and performed a chip array or RT-PCR assays, respectively. The gene discussed is NRIP1; the disease is breast cancer.