In contrast, we identified monocytes/macrophage in the liver as well as BM as a target of EVs in ALI model, which serially revealed that the recruitment of neutrophils releasing ROS, was attenuated via downregulation of CXCL1 and CXCL2 (Figs. 2–4), mainly secreted from macrophages [31]. This evidence concerns the gene CXCL1 and acute respiratory distress syndrome.