RCAN1, the specific endogenous inhibitor of Calcineurin, has been reported participating in various physiological functions, including regulating VEGF-mediated tubular morphogenesis in endothelial cells, leading to directed cell migration [28], influencing metabolism and thermogenesis [19], defending against oxidative stress mediated by calcium [29], inhibiting growth, angiogenesis, and metastases of hepatocellular carcinoma [23]. Here, RCAN1 is linked to hepatocellular carcinoma.