CD169-positive monocytes are positively correlated with severe COVID-19 progression.49 CD169+ macrophages have been identified as a key subgroup of macrophages resident in lung tissue and significantly promoted the progression of inflammation.50 IFN-induced ACE2 expression in macrophages triggers inflammatory signals and CD147 in monocytes also participates in virus invasion and inflammation progression.48 Here, SIGLEC1 is linked to COVID-19.