Elevated chemokines such as CXCL1, CXCL2, CXCL5, and CXCL8 recruit neutrophils by binding the chemokine receptor CXCR2 to the tumor microenvironment.25,30 The majority of clinical evidence suggests that NLR and neutrophilia are independent prognostic markers for many types of cancer. The gene discussed is CXCL8; the disease is cancer.