Indeed, disease-causing mutations in many RNA-binding proteins conspicuously cluster in LCDs in association with ALS, FTD, IBM, or a combination of these conditions, a pattern that has been observed for not only hnRNPA1 and hnRNPA2 (Kim et al. 2013, 2021; Liu et al. 2016; Qi et al. 2017; Naruse et al. 2018; Beijer et al. 2021) but also TDP-43 (Sreedharan et al. 2008), FUS (Kwiatkowski et al. 2009), TIA1 (Klar et al. 2013; Mackenzie et al. 2017), matrin 3 (Johnson et al. 2014), and hnRNPDL (Vieira et al. 2014). The gene discussed is MATR3; the disease is amyotrophic lateral sclerosis.