Indeed, abnormal redistribution of RNA-binding proteins from the nucleus to the cytoplasm, including TDP-43, may be the most prominent histopathological feature of ALS-FTD (Honda et al. 2015; Koyama et al. 2016; Fifita et al. 2017) and genetically related myopathies (Picchiarelli and Dupuis 2020). This evidence concerns the gene TARDBP and frontotemporal dementia.