RNPC3 and amyotrophic lateral sclerosis: First, given the importance of RNP condensates to governing RNA metabolism, and the fact that many of the ALS-FTD-causing mutations in RNA-binding proteins impact mRNPs that are constituents of multiple condensates and traffic between them, one might expect ALS-FTD-causing mutations that alter the dynamics and material properties of RNP granules to cause pleiotropic defects in RNA metabolism.