TARDBP and amyotrophic lateral sclerosis: For example, ALS-causing mutations in FUS and TDP-43 promote hardening of RNA transport granules in neurons (Alami et al. 2014; Murakami et al. 2015; Gopal et al. 2017), which correlates with impairment in their microtubule-dependent axonal transport (Alami et al. 2014; Gopal et al. 2017).