At least eight ALS-FTD- or IBM-associated genes encode RNA-binding proteins (TDP-43 [Kabashi et al. 2008; Sreedharan et al. 2008], FUS [Kwiatkowski et al. 2009; Vance et al. 2009], hnRNPA1 [Kim et al. 2013; Liu et al. 2016], hnRNPA2B1 [Kim et al. 2013], matrin 3 [Johnson et al. 2014], TIA1 [Mackenzie et al. 2017], hnRNPDL [Vieira et al. 2014], and annexin A11 [Smith et al. 2017; Leoni et al. 2021]); in addition, the disease-associated gene ANG encodes angiogenin, a tRNA processing protein (Greenway et al. 2006). This evidence concerns the gene MATR3 and amyotrophic lateral sclerosis.