Thus, although the full pathogenic course of ALS-FTD is undoubtedly multifactorial, converging evidence suggests that a substantial fraction of ALS-FTD is caused by disturbance in properties of RNP granules and other biomolecular condensates with adverse consequences for multiple aspects of RNA metabolism, ultimately leading to neuronal dysfunction and demise. Here, RNPC3 is linked to amyotrophic lateral sclerosis.