NOD2 and peritonitis: Moreover, MYSM1 can remove the polyubiquitination chain at the K63, K27 and M1 loci in PI(4,5)P2 triggered by NOD2 signaling, thus inhibiting peritonitis, systemic inflammatory responses and liver injury [30]; this indicates that MYSM1 can probably regulate AKT at an upstream site, which further suggests that MYSM1 is involved in the transduction of PI3K/AKT signaling.