This study showed that increased protein expression of nuclear Nrf2 is accompanied with an increase of Akt activation (phosphorylation) and GSK3β inactivation (phosphorylation) after UTE and URE treatment in the STZ-induced AD model, indicating that Akt(Ser473)/GSK3β(Ser9) may mediate the neuroprotective effects of UTE and URE. This evidence concerns the gene AKT1 and Alzheimer disease.