BRCA2 and breast cancer: Dennis J et al. in 2010 conducted a case-control study of 1925 premenopausal women who carried a BRCA 1 or BRCA 2 mutation to investigate alcohol consumption and the risk of breast cancer, reporting an inversely proportional association between alcohol intake and increased risk of developing BC only in BRCA1-mutated women, while no association was found in BRCA2-mutated women (OR = 0.82; 95% CI 0.70–0.96) vs OR = 1.00; CI 0.71–1.41) [30].