On the other hand, autophagy induction causes a decrease in the levels of transcription factors triggering EMT [120], reduces 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3) expression and elicits metastatic dormancy in breast cancer stem cells [121]. This evidence concerns the gene PFKFB3 and breast carcinoma.