Kokuryo [11] used siRNA to interfere with the expression of NEK2 in biliary epithelial cancer cells and fibroblasts, and the results showed that the inhibition of NEK2 could significantly inhibit the proliferation of biliary epithelial cancer cells but had no effect on the proliferation of normal fibroblasts, suggesting that the targeted inhibition of NEK2 is highly selective for tumor cells. This evidence concerns the gene NEK2 and neoplasm.