Additionally, in vitro experiments demonstrated that in the groups with high Axin2, the proliferative, migratory and invasive abilities of CC cells were relatively stronger, while the cancer-promoting effect of circ_0038718 was reversed in the pcDNA-circ_0038718 + miR-195-5p mimic group and pcDNA-circ_0038718 + sh-Axin2 group (Fig. 6C-E). This evidence concerns the gene AXIN2 and cancer.