When associated with multiple risk factors, proteins were either consistently elevated with increased risk, for example, ERG (Figure 1B, red box); detected at higher levels with increasing BMI, LDL, smoking, and hypertension (+ sign), or consistently reduced with elevated risk, for example, HEG1 (Figure 1B, green box); detected at lower levels with increasing BMI, LDL, and hypertension (− sign). The gene discussed is HEG1; the disease is hypertensive disorder.