Examining 352 TCGA prostate cancer patient samples that have both RNA-seq mRNA and RPPA proteomics data, we found that p-S473-AKT level is higher (P = 0.0032) in 36% of patient samples that have lower levels of CKB expression (Z score <-0.5) (Fig. 5E). This evidence concerns the gene CKB and Familial prostate cancer.