In keeping with the phenotypic loss of HEVs in tumor LNs, the expression levels of Glycam1, Chst4, Icam1, and Ccl21a were progressively reduced in HEC1 to HEC3 (Figure 3C), similar to the reduction of gene expression of PNAd producing glycan-generating enzymes (Lee et al., 2014) (Figures S3F and S3G). This evidence concerns the gene CHST4 and neoplasm.