In contrast to infection models (Liao and Ruddle, 2006; Tzeng et al., 2010; Dasoveanu et al., 2016), lymphoma did not allow a recovery of HEVs, FRC-derived CCL21 expression, or the conduit network, although lymphoma B cells potentially can activate LTβR signaling (Rehm et al., 2011; Gloger et al., 2020). This evidence concerns the gene LTBR and infection.