Adoptively transferred naive CD4+ OT-II T cells (CD44low) showed T cell receptor (TCR)-specific activation in control and tumor LNs after immunization with ovalbumin; however, the strongly impaired T cell homing to LNs with tumor was also associated with a decreased number of activated CD4+OT-II+CD44high cells (Figure S4E and S4F). The gene discussed is CD4; the disease is neoplasm.