In keeping with the phenotypic loss of HEVs in tumor LNs, the expression levels of Glycam1, Chst4, Icam1, and Ccl21a were progressively reduced in HEC1 to HEC3 (Figure 3C), similar to the reduction of gene expression of PNAd producing glycan-generating enzymes (Lee et al., 2014) (Figures S3F and S3G). The gene discussed is NTAN1; the disease is neoplasm.