However, single‐cell clones derived from CRISPR‐Cas9‐mediated SF3B1 gene editing in Mel202 cells (heterozygous SF3B1 mutation) retain at least one functional wild‐type allele with in‐frame editing, which is concordant with previous findings that cancer cells bearing SF3B1 mutations exhibit dependency on the remaining wild‐type SF3B1 allele, but not the mutant allele, for survival [30, 41]. Here, SF3B1 is linked to cancer.