ASIC3 and osteoarthritis: It is a pain modulator expressed in the knee joint, strongly correlated with weight-bearing pain and secondary hyperalgesia.7 In a hind-paw osteoarthritis model, ASIC3 was expressed in dorsal root ganglia after 21 days.8 Furthermore, ASIC3 can effectively transduce the prolonged tissue acidosis occurring in osteoarthritis pathology.9