However, our results clearly indicate that: 1) BAFF plays a protective role during primary Salmonella infection, and 2) this is most likely due to the regulation of B cells, given that BAFF-producing DCs and Nphs are required for the early up-regulation of specific B cell subsets and the Salmonella-specific IgM Abs induced by systemic acute infection. The gene discussed is CD40LG; the disease is Salmonella Infections.