In a multivariate logistic regression model, the age-adjusted OR for predicting cervical cancer lesions were independently significant for p16/TOP2A biomarkers in archived FFPE cervical tissues [p16: OR = 1.142 (95% CI: 1.059–1.232, p<0.001) and TOP2A: OR = 1.046 (95% CI: 1.008–1.085, p = 0.015)]. This evidence concerns the gene TOP2A and cervical carcinoma.