In addition, a 40% difference in the expression of p16 (high) versus TOP2A (high) biomarkers (100% versus 60%) observed in the squamous cell carcinoma may imply that the p16 biomarker is more specific for squamous cell carcinoma than the TOP2A biomarker [22, 24, 31, 37]. This evidence concerns the gene TOP2A and squamous cell carcinoma.