Considering the co-expression of CD68 and α-SMA may contribute to the macrophage-to-myofibroblast transition [38, 39], especially during renal fibrosis [40], it may partially support the explanation that the more severe lesions in the gadodiamide group were because of the high expression of CD68 and α-SMA. This evidence concerns the gene CD68 and renal fibrosis.