Given that IGF2BP2 had obvious abnormal expression in AD, we also explored the expression of canonical systemic inflammation biomarkers as well as AD pathological markers [45, 46] in IGF2BP2_high and IGF2BP2_low subgroups defined by the median expression value of IGF2BP2 in both GSE33000 and GSE48350/5281 datasets (Figure 2F, 2G). Here, IGF2BP2 is linked to Alzheimer disease.