To verify whether liver-mediated secretion of the cFGF23-albumin fusion was able to rescue phosphate wasting in the Hyp-Duk mouse, a murine model of XLH, an AAV8 vector expressing the cFGF23co-albumin fusion with the clFIX cleavable linker (from now on called AAV-cFGF23) was injected in 4-week-old Hyp-Duk mice at the dose of 1 × 1012 vg per mouse (Hyp-Duk, AAV-cFGF23). This evidence concerns the gene ALB and X-linked hypophosphatemia.