For example, gain‐of‐function mutations in the NLRP3 gene are linked to cryopyrin‐associated periodic fever syndromes (CAPS), a group of rare hereditary autoinflammatory diseases, including familial cold urticaria, Muckle–Wells syndrome, and neonatal onset multisystem inflammatory disease (Hoffman et al, 2001; Hoffman & Wanderer, 2010). The gene discussed is NLRP3; the disease is cryopyrin-associated periodic syndrome.