To gain an understanding of this difference, we first extended our previous finding that lung DCs in COPD have increased expression of markers of maturation and activation, including CD40, CD80, and CD86 (14), by examining CCR2, CCR7, and CX3CR1, which are chemokine receptors involved in DC maturation and trafficking (23–25). This evidence concerns the gene CCR2 and chronic obstructive pulmonary disease.