A very recent study reports that endogenous VPS35 protein levels and other retromer subunits are selectively reduced in spinal cord motor neurons in ALS-linked G93A SOD1 mice, as well as in ventral horn motor neurons from sporadic ALS brains and iPSC-derived motor neurons derived from ALS subjects bearing SOD1 mutations.21 The gene discussed is VPS35; the disease is amyotrophic lateral sclerosis.