Underscoring this concept, mutations in the Vacuolar Protein Sorting 35 Orthologue (VPS35) gene have been identified to cause late-onset, autosomal dominant familial Parkinson’s disease, whereas reduced VPS35 protein levels are reported in vulnerable brain regions of subjects with Alzheimer’s disease, neurodegenerative tauopathies such as progressive supranuclear palsy and Pick’s disease, and amyotrophic lateral sclerosis. This evidence concerns the gene VPS35 and Classical progressive supranuclear palsy.