HPRT1 and cancer: When OA-induced ROS were removed by the antioxidant N-acetyl-l-cysteine (NAC), phosphorylated AMPK at Thr172, phosphorylated ACC at Ser79, and LC3-II isoform were all restrained, while OA-induced HGPRT and 5′-NT degradation was blocked; thus, cancer cell growth was recovered (Figures 6E–6G).