To improve the safety of CAR-transduced T cells, we previously designed a natural multi-chain immunoreceptor CAR based on the DNAX-activating protein of 12 kDa (Dap12) signaling domain for the first time, which triggers antigen-specific cytotoxicity, cytokine production, and proliferation that is comparable with CD3z-based CARs ex vivo/in vitro for hematological malignancies.9 The gene discussed is TYROBP; the disease is hematologic disorder.